Frein

Healing Touch from Revised Bhaalpowers does not appear to work on the demon in Amaunator's temple (spell ineffective). I doubt this is intended.

Have you tried backing up minsc.bsc, clearing it until you have removed the cursed item, then restoring it?

I actually had a problem with my installation of infinity animations. My issue has been solved for some time now.

Update (just registered and can't edit guest posts):

It doesn't seem to have anything to do with characer scripts or currently worn equipment. I can unequip my stuff and erase AI scripts with NI and it still happens. Also, apparently a move command does not always cancel the warp. I noticed this while testing the bug at the inn at the city gates in BG2. Issuing a move command cancels the warp when moving out of the inn but not when going back inside. Also, the timing of the warp seems inconsistent. In some areas it takes perhaps a whole second or more, other times only half a second or so. I think it may have something to do with how large the area you're loading is.

OP: do you have Full Plate and Packing Steel installed? Apparently v2 of that mod can cause this behaviour by spawning an invisible object for some technical reason. It should be fixed in the v3 beta, which I'm going to try soon.

Have you tried installing generalized biffing and/or taking a look at the NVidia thread (both in my sig)?

Other than that, no helpful clue - Refinements was running just fine on 2002-era computers.

I didn't try biffing with Refinements but once I started to experience some slowdown after installing several additional mods, I got it and the game became smooth as silk once again. I may try combining them for my next game.