Interesting thing about some of the 'fourth wall breakage', at least in
BG, is that it falls into two categories: Simple Humor and Satire.
Larry, Darryl and Darryl were simple humor. A little reference in there to get a laugh.
Bondari and even Chinchilla is some rather egregious satire. Bondari mocks the rather common 'try, fail, reload, try different way' procedure many gamers experiment with. Chinchilla is a bit of 'not all powerful beings look like they are. Super powered bunnies? Well, anyone who has watched Monty Python knows they exist, but still.
Now, the argument over whether they were well written jokes... well... I enjoyed them but they could have been a lot better written. Heck, all of
ToB could be a lot better written. A lot.
As to the humor/drama element... I know some people prefer a serious, dramatic look at things, but life is funny. Comedy exists. It exists even in Shakespeare's darkest tragedies or in Euripedes. And Aristophanes was pure comedian, but that didn't demean his work. I doubt Jonathan Swift could have more eloquently and effectively put forth the disasterous conditions in Ireland if A Modest Proposal was serious tract about all the suffering and how some food shipments might resolve it. However, Truman Capote's In Cold Blood probably wouldn't have been so powerful if it was a dark comedy instead of the serious story it was.
In summary, both work, both can be equally effective. However, the reader has to be receptive to the message in the book. The quality of the writing AND the mindset of the reader are what determines whether or not it works.