I. Mass Effect 2
This is the number one for me as I really liked ME1 and from what I've seen, ME2 is only going to be better in almost every aspect. Not too long to go before the launch either.
II. Fallout: New Vegas
I genuinely liked FO3 because of its relaxing effect, so this one is a no brainer. I guess you could argue that shooting mutants in the desert isn't exactly relaxing, but hey, I relax by playing shooters, or shooter-action-roleplaying-sandbox games in this case (SARS for short

III. Alpha Protocol
I'm hoping to find some of the magic DX1 had in its day in this game. I haven't really followed its development, so I'll just let myself be surprised and go buy it blind, so to speak. Maybe it will even make me like stealth games.