Hmm, bit of a list still in the works, nonetheless:
BG1Alora - That... damn song. Stop singing it already!!
Eldoth - Guess.
Skie - That damn soundtrack nearly sent me deaf. Note to self; never to have volume turned up when she's present.
BG2Anomen - Most reasons kind of obvious, the thing that disturbs me most is the constant hot & cold sessions with the female PC. Although like Edwin, he is fun to make fun of, so he has earned a redemption point as far as I'm concerned.
Selfish - Yup, this guy too. I hate having to take the good path to save a perfectly good
NPC, even if I've done the worst kind of evil path throughout the game. (namely do the jobs, then murder everyone in sight for
XP well, nearly everyone.)
KotOR2Disciple (Mical) - Something about this one really ticks me off, perhaps the inability to have a significantly different view on the Republic? Hm, have to think on that. Regardless, in practical terms he always turns out a bit average in comparison to the others, don't know why Atton is so jealous when this guy is around, nope, no idea at all.
Vrook - Arrogant, holier-than-thou etc, etc. It's a good thing he was actually intended to be a jerk to our poor Exile.
Tactics Ogre: Let us Cling TogetherKachua - Perhaps the only person in the game that really gripes me with their personal issues, essentially an attention seeker with a bit of a overboard way of going about things. Invaluable as an
NPC though so there are some good qualities, and some moments are heartwarming enough to ward off scorn.
Duke Ronway - If you've ever done the Chaotic Path in this game, then you know precisely why I hate him. For those that haven't though, make a list of Lord Nasher's qualities from NWN1, and then mix it in a cocktail of Bodhi's schemes.
Command & Conquer 1Seth - Yup, what's not to dislike about this guy's obvious disdain for those beneath him?
Sure was rewarding to see him go... until I noticed what level I was on, then I hated Kane even more.
Fallout 2Elder of Arroyo - Wait! You want me to go out and search for some 'holy device' ALONE?! Since when did we pick the straws and.. oh nevermind, I'll just sulk some more, maybe join a slaver's guild or a New Reno crime family. Let's see you be so happy about sending out ONE person to find the GECK then! Hmph.
Ok, that's out of the system. Essentially the plotline built upon the Elder seems a little iffy at best, in a world that's been pretty much nuked to near-death status, she sends out one of her kids alone into the wasteland, with hardly anything of practical value and very few clues on where to start out looking for the GECK. Chances of success are obviously near nil for the average person, suppose that's why the name Chosen One keeps popping up so regularly.
Still, seeing her later in the game did change a few biases a little, alas, not enough to get rid of the grumbling though.
Renesco - Don't know what exactly this guy has against monthly extortion and accusations of murder. But seriously, he needs to pull that nose of his back a little, yeesh.
First Citizen Lynette - Obviously the most upstanding citizen of Vault City, both in rank, and tightn--err, snobbery.
Generally dislikeable until much later, but nonetheless I love making her angry, the angry face is just the best around for this one.
Myron - This guy is creepy, crazy, and a total sadist by the sounds of him. If he was older, I bet would become the next Frankenstien - maybe creating a walking Jet Monster.
Pretty useless as an
NPC though, I say it's best to leave him in Golgotha, doesn't matter in what way. Only redeeming quality I reckon would be the ability to create new drugs at minimal expense, such as stimpacks, though outdated really when he comes along - it makes for easy money, true to New Reno style.
Many more to name, but I'll stop there for now.