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For those interested, I have compiled the information regarding all the upcoming changes in the Realms (4th Edition) I could find in one neat post. I did not write the following and do not have details for any of these events as I have merely found them on other sites and compiled them. The following is obviously full of spoiler-ish material.
In 1384 DR, Siamorphe quarreled with Tyr as they took different sides in a clash between Tethyr and Calimsan. She removed herself from the House of the Triad and joined Sune's court in Brightwater.
Try sent Helm to plead his case with Sune and she suggested a marriage between Tyr and Tymora to set the celestial planes in balance again.
Helm conveys Sune's suggestion to Tyr and begins to chaperone a chaste courtship between the two.
Strange and fateful misunderstandings lead to the accusation that Helm has stolen Tymora's heart while conveying the gifts and sentiments of Tyr. A strict interpretation of his own ideals forces Tyr to challenge Helm, and Helm is obliged by his own beliefs to meet the challenge.
They do battle and Tyr kills Helm before coming to his senses. Heartbroken, Tymora accompanies Tyr back to the House of the Triad. Though it can't be proved, the gods sense Cyric's hand in Helm's death.
As a side note, Ilmater removes his domain to from the House of the Triad to Brightwater, at Sune's invitation.
Though nothing can be proved, the gods believe that Cyric is somehow involved in Helm's death.
In 1385 DR, With help from Shar, Cyric murders Mystra in Dweomerheart, destroying the plane and Savras, as well as sending Azuth and Velsharoon into the Astral plane.
Magic bursts from the bonds of the Weave. Thousands of mages are driven insane or destroyed, and the very substance of the world becomes mutable beneath the veils of azure fire that dance across the sky.
Cyric is imprisoned on his home plane for 1,000 years by Tyr, Lathander, and Sune for his crimes. This event is what is known as the Spellplague.
Apparently many planes are "shifted" or destroyed. The book states that only the greater gods can protect their respective planes from the destruction. This implies that some of the lesser [and intermediate] gods might not make it.
The last sentence of the book says that the Weave is destroyed and the "old world" ends and a new one begins. What that means is anybody's guess.
Although this has already been revealed in the novels, most of the Drow gods have been axed. All that's left is Lolth, Eilistraee, and Ghaunadaur. Later Ghaunadaur is attacked by Lolth and moves to the Deep Caverns.
And in 1383 a bunch of dwarven deities bite it. Gorm, Heala, Laduguer, and Deep Duerra die in battle with each other. The book says that Hammergrim "disperses" into the Astral.
The sample chapter for the Orc King (by R.A. Salvatore) gleans some glimpse of the future of Realms.
The Spellplague devastates most of the Realms in some fashion. Hundreds of thousands of people die in the chaos of the Spellplague. The Empire of Nethril rises, the aboleths become a problem. This is a reference to the colliding of two worlds though if this is literal event or bardish prose, I don't know.
The Silver Marches apparently are no more though Silverymoon survives. To survive, a very loose alliance with Obould Many-arrows.
The Orcs establish a permanant Kingdom in the North.
Myth Drannor's mythal is restored. Srinshee returns of Myth Drannor and give Ilsevele Miritar the Rule's Blade to become coronal. Queen Amlaruil returns to Myth Drannor, planting the Tree of Souls there.
Cormyr goes to war with Shade after Alusair executes a spy. Avoun V comes of age and becomes the King. He's having problems with his nobles.
Moradin leads an attack on Hammergrim and destroys it.
Halaster is dead.
Blackstaff is dead.
Selune has been laid to rest, she's really dead now, no longer a ghost.
Elminster is in hiding.
